Universal Serologic Reaction in Rabbit Syphilis*

Universal serologic reaction in leprosy.

It has long been known that the serum of certain leprosy patients gives positive reactions with tests for syphilis. These reactions have not been understood and have been interpreted as biologic ‘(false positives.” The reason for this interpretation undoubtedly lies in the widespread assumption that only in syphilis and in closely related diseases, such as yaws and bejel, are serum reactions wi...

Experimental Syphilis of Oriental Origin: Clinical Reaction in the Rabbit

Two oriental strains of T. pallidum of Chinese origin were compared with two well known occidental strains, the Nichols and the Zinsser-Hopkins, on the basis of the clinical reaction to infection in the rabbit. Four experiments were carried out, two each in Peiping and New York. Animals from American and Chinese sources were represented in each experiment. The results obtained showed that the r...

Serologic Response to Treatment in Syphilis

Serologic monitoring is the way to determine adequate treatment response, which is typically defined as a fourfold decline in Rapid Plasma Reagin (RPR) or Veneral Disease Research Laboratory (VDRL) titer within 6 months of treatment for patients with primary or secondary syphilis and within 12 months of treatment for patients with early latent syphilis. Studies documented close to 100% rate ser...

Experimental Syphilis in the Rabbit

In a series of more than 200 rabbits in which generalized lesions were observed following local inoculation with Treponema pallidum, there were a number of animals in which characteristic lesions were noted upon mucous membranes or along mucocutaneous borders. These lesions were distributed with about equal frequency between the nose or nasolacrimal system and the eyelids on the one hand, and t...

Experimental rabbit syphilis.